Understanding how biological aging affects cognitive resilience in stroke survivors
Official title: Biological Aging, the Proteome and Cognitive Resilience among Ischemic Stroke Survivors
Funded at Columbia University Health Sciences · NIH-10808121 · Data updated 2026-11-12
This study is looking at how aging affects brain health in older adults who have had strokes, using blood samples to find ways to help them think better and possibly delay memory problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 15, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $130,842 |
| NIH project number | 5K99AG075196-02 |
| Project ID | NIH-10808121 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who have survived an ischemic stroke and are at risk for cognitive impairment or dementia.
✕Less likely to help
Patients who have not experienced a stroke or who are not in the older adult age group may not benefit from this research.
What this research studies
This research investigates the relationship between biological aging and cognitive resilience in older adults who have survived ischemic strokes. By examining the proteome, which consists of all the proteins in the body, the study aims to identify molecular mechanisms that influence cognitive health and the onset of dementia. The research focuses on using accessible tissue samples, such as blood, to explore these connections in a vulnerable population. Ultimately, the goal is to uncover factors that could help delay cognitive decline and improve quality of life for stroke survivors.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cognitive decline and dementia in older adults who have experienced strokes.
How similar studies have gone: While the specific approach of assessing the proteome in stroke survivors is novel, similar studies have shown promise in understanding cognitive resilience and aging.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Waziry, Reem — Columbia University Health Sciences
- Study coordinator: Waziry, Reem
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.