Understanding how biofilms affect the immune response to surgical implants
Implant Biofilm Mediated Immune Response
This study is looking at how the immune system reacts to the germs that can build up on surgical implants, like breast and joint implants, to help understand why some people have problems after their surgeries and to make these procedures safer and more effective for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10886023 on NIH RePORTER |
What this research studies
This research investigates the interactions between the immune system and biofilms that can form on surgical implants, such as breast and joint implants. It aims to uncover the mechanisms behind complications that some patients experience after receiving these implants, including symptoms related to autoimmune conditions. By studying these interactions, the research seeks to improve the safety and effectiveness of implant surgeries, ultimately enhancing patient outcomes. The study will involve analyzing biological samples and patient data to identify patterns and potential solutions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with breast or joint implants who are experiencing unexplained symptoms such as chronic fatigue or autoimmune-like conditions.
Not a fit: Patients without surgical implants or those not experiencing any complications related to their implants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for patients experiencing complications from surgical implants.
How similar studies have performed: Previous research has shown promising results in understanding the immune response to biofilms in other medical contexts, suggesting potential for success in this area as well.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Sinha, Mithun — Indiana University Indianapolis
- Study coordinator: Sinha, Mithun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.