Understanding how biobehavioral factors affect depression in adolescents

Biobehavioral Predictors of Illness Progression in Adolescent Depression

NIH-funded research University of Miami School of Medicine · NIH-11004468

This study is looking at how different biological and behavioral factors affect the way depression develops in teenagers, with the hope of finding better ways to help them feel better.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Miami School of Medicine NIH-funded
Lab location1 site (Coral Gables, United States)
Project IDNIH-11004468 on NIH RePORTER

What this research studies

This research investigates the factors that influence the progression of depression in adolescents, focusing on how biological and behavioral elements interact. It aims to identify predictors of illness trajectory by examining the role of inflammation and neurochemical changes in the brain. By using advanced imaging techniques, the study will explore how these factors contribute to symptoms like anhedonia, which is a key feature of depression. The goal is to inform treatment strategies that can better address the course of depression in young people.

Who could benefit from this research

Good fit: Ideal candidates for this research are adolescents experiencing symptoms of depression, particularly those showing signs of anhedonia.

Not a fit: Patients who are not adolescents or those who do not exhibit depressive symptoms may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatment approaches for adolescent depression, potentially reducing its severity and duration.

How similar studies have performed: Previous research has shown promising results in understanding the neurobiological underpinnings of depression, suggesting that this approach could yield valuable insights.

Where this research is happening

Coral Gables, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.