Understanding how binge drinking affects brain cells and behavior
Official title: Project 1: The Reciprocal Relationship between Binge Drinking and Astrocytic Signaling
Funded at North Carolina Central University · NIH-10897321 · Data updated 2026-11-12
This study is looking at how binge drinking affects certain brain cells and how this might help us find new ways to help people cut back on drinking, especially by understanding differences between men and women.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina Central University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 20, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $189,152 |
| NIH project number | 5U54AA030451-03 |
| Project ID | NIH-10897321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who engage in binge drinking and may be at risk for alcohol dependence.
✕Less likely to help
Patients who do not consume alcohol or have no history of binge drinking may not benefit from this research.
What this research studies
This research investigates the relationship between binge drinking and the signaling of astrocytes, a type of brain cell, to find new ways to reduce excessive alcohol consumption. It focuses on how binge drinking activates astrocytes and the neuroimmune system, particularly in the hippocampus, which is crucial for memory and behavior. The study also examines how sex differences influence these processes and whether modifying astrocytic signaling can reverse the negative effects of alcohol on brain function and drinking behavior. By exploring these mechanisms, the research aims to identify potential targets for interventions to combat alcohol dependence.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help reduce binge drinking and its associated health risks.
How similar studies have gone: Previous research has shown that targeting neuroimmune responses can be effective in addressing alcohol-related behaviors, suggesting a promising avenue for this study.
Where this research is happening
-
North Carolina Central University
Durham, United States Active
Researchers
- Principal investigator: Marshall, Simon Alexander — North Carolina Central University
- Study coordinator: Marshall, Simon Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.