Understanding how BIN1 affects brain cell function in Alzheimer's disease
Official title: Unlocking BIN1 function in oligodendrocytes and support of axon integrity
Funded at Texas A&m Agrilife Research · NIH-10901005 · Data updated 2026-11-12
This study is looking at how a protein called BIN1 affects brain cells that help keep nerve fibers healthy, to see if changes in these cells might play a role in the early stages of Alzheimer's disease, even before symptoms show up.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m Agrilife Research NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $466,531 |
| NIH project number | 1R56AG083942-01 |
| Project ID | NIH-10901005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are at risk for or diagnosed with late-onset Alzheimer's disease.
✕Less likely to help
Patients with early-onset Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
What this research studies
This research investigates the role of a protein called BIN1 in oligodendrocytes, which are cells that support the health of nerve fibers in the brain. The study focuses on how changes in these cells may contribute to the early stages of Alzheimer's disease, particularly before the more recognizable symptoms appear. By examining the cellular mechanisms involved, the researchers aim to uncover how BIN1 influences the integrity of axons, the long projections of nerve cells that are crucial for communication in the brain. This could lead to new insights into the disease process and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the underlying cellular mechanisms involved in nerve cell health.
How similar studies have gone: While the specific role of BIN1 in oligodendrocytes is less explored, similar research has shown that targeting cellular mechanisms in neurodegenerative diseases can yield promising results.
Where this research is happening
-
Texas A&m Agrilife Research
College Station, United States Active
Researchers
- Principal investigator: Li, Jianrong — Texas A&m Agrilife Research
- Study coordinator: Li, Jianrong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.