Understanding how bile duct diseases lead to liver fibrosis
Molecular Mechanisms of Cholestatic Fibrogenesis
This study is looking into how problems with bile ducts can lead to liver scarring and damage, and it aims to find new ways to help prevent or treat this condition by understanding the signals that damaged cells send out.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11003324 on NIH RePORTER |
What this research studies
This research investigates the biological processes involved in cholestatic fibrogenesis, which is the development of fibrosis in the liver due to bile duct diseases. It focuses on how damaged bile duct cells release signaling molecules that activate liver cells, leading to excessive scarring and liver damage. The study employs advanced techniques to analyze the genetic and epigenetic factors that contribute to this process, particularly the role of long non-coding RNAs in regulating gene expression. By understanding these mechanisms, the research aims to identify potential therapeutic targets for preventing or treating liver fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from cholestatic liver diseases, such as biliary cirrhosis or biliary atresia.
Not a fit: Patients with liver diseases not related to bile duct dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse liver fibrosis in patients with bile duct diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of signaling pathways in liver fibrosis, indicating that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Huebert, Robert Christian — Mayo Clinic Rochester
- Study coordinator: Huebert, Robert Christian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.