Understanding how bile duct cells communicate during injury
Official title: Mechanisms regulating cellular crosstalk in extrahepatic bile duct responses to injury
Funded at University of Michigan at Ann Arbor · NIH-11053616 · Data updated 2026-11-12
This study is looking at how cells in the bile ducts react when they get hurt, especially in people with cholangiopathy, to find out what causes inflammation and extra cell growth, with the goal of helping develop better treatments for those dealing with bile duct issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $484,845 |
| NIH project number | 5R01DK139012-02 |
| Project ID | NIH-11053616 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 40 years old who are diagnosed with cholangiopathies or related bile duct disorders.
✕Less likely to help
Patients with bile duct disorders who are older than 40 or those with conditions unrelated to cholangiopathy may not benefit from this research.
What this research studies
This research investigates the cellular interactions that occur in the bile ducts when they are injured, particularly focusing on a condition known as cholangiopathy. It aims to uncover the mechanisms that lead to inflammation and excessive cell growth in the bile ducts, which can result in serious complications like cirrhosis and cancer. By studying the responses of different cell types involved in this process, the research hopes to provide insights that could lead to better treatments for patients suffering from bile duct disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cholangiopathies and preventing their severe complications.
How similar studies have gone: Previous research has shown promise in understanding cellular interactions in other organ injuries, suggesting that this approach could yield valuable insights, although the specific focus on bile duct injury is relatively novel.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Razumilava, Nataliya — University of Michigan at Ann Arbor
- Study coordinator: Razumilava, Nataliya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.