Understanding how Bicaudal-C controls protein production in cells
Official title: Mechanisms of mRNA-selective control by Bicaudal-C
Funded at University of Wisconsin-Madison · NIH-11133024 · Data updated 2026-11-12
This study is looking at how a protein called Bicaudal-C helps control the production of other important proteins that affect how our cells grow and work, which could help us understand certain health issues better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $525,109 |
| NIH project number | 5R01GM152615-02 |
| Project ID | NIH-11133024 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals with conditions related to cell development and function, particularly those affecting the nervous system.
✕Less likely to help
Patients with conditions unrelated to cell fate decisions or protein regulation may not receive any benefit from this research.
What this research studies
This research investigates the role of a protein called Bicaudal-C in regulating the production of other proteins that are crucial for cell development and function. By focusing on how Bicaudal-C interacts with specific RNA molecules, the study aims to uncover the mechanisms that guide cell fate decisions during development and in adult organisms. The research employs advanced molecular biology techniques to analyze these interactions and their implications for health and disease. Patients may benefit from insights gained about how disruptions in these processes can lead to various conditions.
Why it matters
Potential benefit: If successful, this research could lead to new understanding and potential treatments for diseases linked to cell dysfunction.
How similar studies have gone: Other research has shown success in understanding RNA binding proteins and their roles in cell regulation, suggesting that this approach has a solid foundation.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Sheets, Michael D — University of Wisconsin-Madison
- Study coordinator: Sheets, Michael D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.