Understanding how betacoronaviruses enter cells
Official title: Functional Viromics of Betacoronavirus Entry
Funded at Washington State University · NIH-10988300 · Data updated 2026-11-12
This study is looking at how certain viruses, like the one that caused COVID-19, enter human cells, so we can better understand which animal viruses might make people sick and help keep everyone safe from future outbreaks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project start | November 16, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $354,008 |
| NIH project number | 5R01AI179720-02 |
| Project ID | NIH-10988300 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with a history of exposure to coronaviruses or those interested in zoonotic diseases.
✕Less likely to help
Patients who are not at risk for zoonotic infections or those without a history of exposure to coronaviruses may not receive direct benefits from this research.
What this research studies
This research investigates the entry mechanisms of betacoronaviruses, including those related to the 2019 novel coronavirus, by studying their interactions with host cells. Using advanced computational modeling and next-generation sequencing technologies, the team aims to identify which animal viruses have the potential to infect humans. By analyzing the genetic makeup of these viruses and their binding capabilities, the research seeks to uncover critical information that could inform future pandemic preparedness. Patients may benefit from insights gained about potential zoonotic transmissions and the development of preventive measures.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of coronavirus transmission and lead to better strategies for preventing future pandemics.
How similar studies have gone: Previous research on coronaviruses has shown success in understanding their transmission and infection mechanisms, indicating that this approach has potential for impactful findings.
Where this research is happening
-
Washington State University
Pullman, United States Active
Researchers
- Principal investigator: Letko, Michael — Washington State University
- Study coordinator: Letko, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.