Understanding how beta-catenin activation affects liver cancer
Investigating multifactorial beta-catenin activation in hepatocellular cancers
This study is looking at how certain gene changes affect liver cancer, specifically to help find new treatment options for people battling this tough disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project ID | NIH-11004037 on NIH RePORTER |
What this research studies
This research investigates the role of beta-catenin activation in hepatocellular carcinoma (HCC), a severe form of liver cancer with few treatment options. The study focuses on mutations in the CTNNB1 gene that lead to abnormal beta-catenin function, as well as the loss of function mutations in the AXIN1 gene, which are both implicated in HCC development. Using mouse models that mimic human liver cancer, researchers aim to uncover the mechanisms behind these mutations and their impact on cancer progression. The findings could help identify new therapeutic targets for patients suffering from this aggressive cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with hepatocellular carcinoma, particularly those with mutations in the CTNNB1 or AXIN1 genes.
Not a fit: Patients with liver cancer not associated with beta-catenin or AXIN1 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for liver cancer patients, improving treatment options and outcomes.
How similar studies have performed: Previous research has shown promising results in targeting beta-catenin pathways in other cancers, indicating potential for success in this area as well.
Where this research is happening
Honolulu, United States
- University of Hawaii at Manoa — Honolulu, United States (Active)
Researchers
- Principal investigator: Chen, Xin — University of Hawaii at Manoa
- Study coordinator: Chen, Xin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.