Understanding how beta and immune cells adapt in autoimmune diabetes
Adaptive epigenetic mechanisms of beta and immune cells in autoimmune diabetes
This study is looking at how insulin-producing cells in the pancreas can survive the immune system's attack in Type 1 diabetes, and it's for anyone interested in understanding how these cells might keep making insulin even when they're under stress.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10897116 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which beta cells, which produce insulin, adapt to the autoimmune attack seen in Type 1 diabetes (T1D). The team will explore how these cells can survive despite the immune response that typically destroys them, focusing on changes in their genetic expression and epigenetic modifications. By studying both human samples and animal models, the researchers aim to identify factors that help beta cells resist damage and maintain some insulin production even in the presence of autoimmune activity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Type 1 diabetes who may still have some residual insulin production.
Not a fit: Patients with Type 2 diabetes or those who have completely lost insulin production may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving insulin production in patients with Type 1 diabetes.
How similar studies have performed: Previous research has shown promising results in understanding adaptive mechanisms in beta cells, suggesting potential for breakthroughs in treatment.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Herold, Kevan C — Yale University
- Study coordinator: Herold, Kevan C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.