Understanding how beta-amyloid peptides disrupt neuronal membranes in Alzheimer's disease
Molecular Structural Basis of Non-specific Neuronal Membrane Disruption Induced by Early-Stage Beta-Amyloid Peptide Aggregation
This study is looking at how certain proteins related to Alzheimer's disease interact with brain cell membranes, which might help us understand how they cause damage, and it could lead to new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of Ny,binghamton NIH-funded |
| Lab location | 1 site (Binghamton, United States) |
| Project ID | NIH-10879536 on NIH RePORTER |
What this research studies
This research investigates the molecular interactions between beta-amyloid peptides and neuronal cell membranes, which are believed to contribute to the pathology of Alzheimer's disease. Using advanced solid-state nuclear magnetic resonance (ssNMR) spectroscopy, the study aims to uncover the structural basis of how these peptides cause membrane disruption. By examining these interactions in model liposomes and neuronal cells, the research seeks to identify key processes that lead to neuronal damage. The findings could provide insights into the mechanisms of Alzheimer's disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it due to genetic or environmental factors.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the mechanisms of neuronal membrane disruption.
How similar studies have performed: Previous research has shown promising results in understanding amyloid interactions with membranes, suggesting that this approach could yield valuable insights.
Where this research is happening
Binghamton, United States
- State University of Ny,binghamton — Binghamton, United States (Active)
Researchers
- Principal investigator: Qiang, Wei — State University of Ny,binghamton
- Study coordinator: Qiang, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.