Understanding how beta-amyloid builds up in the brain of Parkinson's disease patients
Official title: Build-up of beta-amyloid in the brain in Parkinson's disease
Funded at Universidad Central Del Caribe · NIH-11089778 · Data updated 2026-11-12
This study is looking at how a substance called amyloid beta builds up in the brains of people with Parkinson's disease as they start to experience dementia, and it aims to find out how this buildup happens and what role blood cells and inflammation play in the process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Universidad Central Del Caribe NIH-funded |
| Lab location | 1 site (Bayamon, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $69,705 |
| NIH project number | 3SC3GM143983-03S1 |
| Project ID | NIH-11089778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease, particularly those experiencing cognitive decline or dementia.
✕Less likely to help
Patients with early-stage Parkinson's disease who do not yet exhibit signs of dementia may not receive direct benefits from this research.
What this research studies
This research investigates the accumulation of amyloid beta (Aβ) in the brains of patients with Parkinson's disease, particularly as they develop dementia. It aims to understand the mechanisms behind this buildup, focusing on the role of platelets and inflammation in the brain. By examining how Aβ interacts with blood vessels and the potential damage it causes, the study seeks to uncover new insights into the progression of Parkinson's disease dementia. The research involves both laboratory experiments and analysis of patient samples to identify key factors contributing to Aβ accumulation.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing or preventing dementia in Parkinson's disease patients.
How similar studies have gone: Previous research has shown that targeting amyloid beta in Alzheimer's disease has potential, suggesting that similar approaches in Parkinson's disease may also yield beneficial results.
Where this research is happening
-
Universidad Central Del Caribe
Bayamon, United States Active
Researchers
- Principal investigator: Inyushin, Mikhail — Universidad Central Del Caribe
- Study coordinator: Inyushin, Mikhail
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.