Understanding how beta-amyloid builds up in the brain of Parkinson's disease patients
Official title: Build-up of beta-amyloid in the brain in Parkinson's disease
Funded at Universidad Central Del Caribe · NIH-10872236 · Data updated 2026-11-12
This study is looking at how a substance called amyloid beta builds up in the brains of people with Parkinson's disease who also have dementia, and it wants to find out if platelets in the blood play a role in this process, which could help us discover new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Universidad Central Del Caribe NIH-funded |
| Lab location | 1 site (Bayamon, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $104,756 |
| NIH project number | 5SC3GM143983-03 |
| Project ID | NIH-10872236 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease, especially those experiencing cognitive decline or dementia.
✕Less likely to help
Patients with early-stage Parkinson's disease who do not yet exhibit symptoms of dementia may not benefit from this research.
What this research studies
This research investigates the accumulation of amyloid beta (Aβ) in the brains of patients with Parkinson's disease, particularly as they develop dementia. It aims to uncover the mechanisms by which platelets may contribute to this buildup and the resulting brain damage. By studying the relationship between platelet activation and Aβ accumulation, the research seeks to identify potential pathways that could be targeted for treatment. The approach includes examining blood samples and brain tissue to understand how Aβ is transported and deposited in the brain.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating dementia in Parkinson's disease patients.
How similar studies have gone: Previous research has shown that targeting amyloid beta in Alzheimer's disease has potential, suggesting that similar approaches may be beneficial in Parkinson's disease, although this specific investigation is relatively novel.
Where this research is happening
-
Universidad Central Del Caribe
Bayamon, United States Active
Researchers
- Principal investigator: Inyushin, Mikhail — Universidad Central Del Caribe
- Study coordinator: Inyushin, Mikhail
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.