Understanding how benzalkonium chlorides affect human health
Interactions between metabolism, transport, and toxicity of benzalkonium chlorides
This study is looking at how certain disinfectants, called benzalkonium chlorides, affect our kidneys and overall health, so we can better understand their safety for people who use these products.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10851979 on NIH RePORTER |
What this research studies
This research investigates the effects of benzalkonium chlorides (BACs), commonly found in disinfectants and other products, on human health. It aims to understand how these substances are metabolized and transported in the body, particularly their potential toxic effects on the kidneys. The study will utilize advanced microphysiological systems to simulate human kidney responses and assess the impact of BAC exposure. By analyzing human plasma samples, the research seeks to establish a clearer picture of how BACs accumulate and their biological consequences.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been exposed to products containing benzalkonium chlorides, particularly those with underlying kidney conditions.
Not a fit: Patients who have not been exposed to benzalkonium chlorides or do not have any kidney-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved safety guidelines and regulations regarding the use of benzalkonium chlorides in consumer and medical products.
How similar studies have performed: While there is some preliminary evidence regarding the toxicity of BACs in animal models, this research is exploring their effects in humans, making it a novel investigation.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Xu, Libin — University of Washington
- Study coordinator: Xu, Libin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.