Understanding how beneficial mutations affect fitness in pathogens
Fitness Effects of Beneficial Mutations
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-11058480
This study is looking at how germs like bacteria and viruses change over time to avoid being killed by medicines, and it’s for anyone interested in understanding why some infections are harder to treat and how we can create better treatments to fight them.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11058480 on ClinicalTrials.gov |
What this research studies
This research investigates the evolutionary processes that influence the progression of cancer and infectious diseases, focusing on how pathogens adapt to evade treatments like antibiotics and antivirals. By tracking the evolutionary changes in these pathogens, the study aims to identify beneficial mutations and their effects on fitness across various environments. The methodology includes isolating adaptive lineages and performing whole genome sequencing to understand how these mutations contribute to drug resistance and treatment failure. This knowledge could lead to the development of novel antimicrobial therapies that are more effective against resistant strains.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections or cancers that are resistant to current treatments.
Not a fit: Patients with non-infectious diseases or those whose conditions do not involve microbial resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that are more effective against resistant infections and cancers.
How similar studies have performed: Previous research has shown success in understanding pathogen evolution and developing new antimicrobial strategies, indicating that this approach has potential.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHERLOCK, GAVIN J — STANFORD UNIVERSITY
- Study coordinator: SHERLOCK, GAVIN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.