Understanding how belief changes affect feelings of persecution

Testing the role of belief updating in persecutory delusions

NIH-funded research Vanderbilt University Medical Center · NIH-11132892

This study is looking at how people with schizophrenia update their beliefs about others, especially when they feel like someone is out to get them, to find better ways to help reduce those scary feelings.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionVanderbilt University Medical Center NIH-funded
Lab location1 site (Nashville, United States)
Project IDNIH-11132892 on NIH RePORTER

What this research studies

This research investigates how the process of updating beliefs influences persecutory delusions, which are the intense feelings that others wish to harm an individual. By examining cognitive processes related to belief updating, the study aims to identify how these processes contribute to the maintenance of such delusions. The research will utilize advanced methodologies to assess how individuals with schizophrenia interpret changes in their environment and how this affects their beliefs. Ultimately, the goal is to develop new treatment approaches that can help alleviate these distressing symptoms.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia who experience persecutory delusions.

Not a fit: Patients without a diagnosis of schizophrenia or those who do not experience persecutory delusions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective treatments for individuals experiencing persecutory delusions, improving their quality of life.

How similar studies have performed: There is growing evidence that cognitive processes related to belief updating play a significant role in delusions, suggesting that this approach may yield valuable insights and potential breakthroughs.

Where this research is happening

Nashville, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.