Understanding how BCOR affects blood clotting and venous thromboembolism
BCOR Regulation of Venous Thromboembolism
This study is looking at how certain genes, especially one called BCOR, might affect the chances of developing blood clots, which can be a serious health issue, and it hopes to find new ways to help prevent or treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10942118 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence the risk of venous thromboembolism (VTE), a serious condition that can lead to significant health complications. The team will focus on the role of a specific gene, BCOR, in regulating the expression of coagulation factors in the liver. By utilizing genome-wide association studies, they aim to identify new genetic links to VTE risk and explore how BCOR interacts with epigenetic regulators to control blood clotting. This could lead to new therapies for preventing or treating VTE.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of venous thromboembolism or those at high genetic risk for developing this condition.
Not a fit: Patients who do not have a history of venous thromboembolism or related coagulation disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that prevent or treat venous thromboembolism, improving patient outcomes.
How similar studies have performed: Previous research has shown success in identifying genetic factors related to blood clotting, making this approach promising for further advancements.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Lowenstein, Charles J — Johns Hopkins University
- Study coordinator: Lowenstein, Charles J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.