Understanding how BCOR affects blood clotting and venous thromboembolism
Official title: BCOR Regulation of Venous Thromboembolism
Funded at Johns Hopkins University · NIH-10942118 · Data updated 2026-11-12
This study is looking at how certain genes, especially one called BCOR, might affect the chances of developing blood clots, which can be a serious health issue, and it hopes to find new ways to help prevent or treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $666,710 |
| NIH project number | 1R01HL174778-01 |
| Project ID | NIH-10942118 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of venous thromboembolism or those at high genetic risk for developing this condition.
✕Less likely to help
Patients who do not have a history of venous thromboembolism or related coagulation disorders may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence the risk of venous thromboembolism (VTE), a serious condition that can lead to significant health complications. The team will focus on the role of a specific gene, BCOR, in regulating the expression of coagulation factors in the liver. By utilizing genome-wide association studies, they aim to identify new genetic links to VTE risk and explore how BCOR interacts with epigenetic regulators to control blood clotting. This could lead to new therapies for preventing or treating VTE.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that prevent or treat venous thromboembolism, improving patient outcomes.
How similar studies have gone: Previous research has shown success in identifying genetic factors related to blood clotting, making this approach promising for further advancements.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Lowenstein, Charles J — Johns Hopkins University
- Study coordinator: Lowenstein, Charles J
Related research
Other NIH-funded projects on the same topics.
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-
Optimal use of blood thinners for venous clots in people with cirrhosis
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-
PET/CT imaging to detect chemotherapy-related vascular harm in young cancer patients
A non-invasive PET/CT scan method using standard care imaging is being tested to identify which pediatric and young adult cancer patients are at higher risk of blood clots from chemotherapy.
-
Statins to Prevent Cancer-Associated Blood Clots in Cancer Patients
A large clinical trial will test whether taking rosuvastatin daily for a year helps prevent dangerous blood clots in people with newly diagnosed or relapsed cancer who aren’t already getting anticoagulants.
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BCOR's role in blood clot risk and liver genetics
A Johns Hopkins-led study is exploring how a human gene, BCOR, may control liver-produced clotting factors to influence venous blood clots.
-
Personalized risk-prediction for hospital-acquired blood clots in adults
A real-time risk model helps doctors identify adults in the hospital who are at higher risk of developing blood clots so they can prevent them safely.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.