Understanding how BCLAF1 affects blood stem cells and their ability to regenerate blood cells
Official title: BCLAF1 regulates expression of AP-1 genes and hematopoietic stem cell repopulating activity
Funded at Washington University · NIH-11074018 · Data updated 2026-11-12
This study is looking at how a protein called BCLAF1 helps control blood stem cells, which are important for making blood cells, and it uses mice to see what happens when this protein is missing, hoping to find ways to improve treatments for blood disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $34,623 |
| NIH project number | 5F31HL165908-02 |
| Project ID | NIH-11074018 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with blood disorders or those undergoing treatments that affect blood cell regeneration.
✕Less likely to help
Patients with stable blood cell production and no underlying hematological conditions may not benefit from this research.
What this research studies
This research investigates the role of a protein called BCLAF1 in regulating hematopoietic stem cells (HSCs), which are crucial for producing blood cells. The study uses mouse models to explore how the absence of BCLAF1 affects the development and function of these stem cells. By examining the changes in blood cell production and stem cell numbers, the research aims to uncover the mechanisms that govern blood cell regeneration and maintenance. This could provide insights into improving treatments for blood-related disorders.
Why it matters
Potential benefit: If successful, this research could lead to better therapies for conditions that affect blood cell production, such as anemia or leukemia.
How similar studies have gone: Previous research has shown that understanding the regulation of stem cells can lead to significant advancements in treating blood disorders, indicating a promising avenue for this investigation.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Crowley, Stephanie — Washington University
- Study coordinator: Crowley, Stephanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.