Understanding how BCAP affects immune signaling in lupus
BCAP regulation of TLR7/9 signaling in Lupus
This study is looking at how a specific protein called BCAP affects certain immune pathways that are important in lupus, with the hope of finding new ways to help manage the condition and reduce harmful antibodies in patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10738273 on NIH RePORTER |
What this research studies
This research investigates the role of BCAP, a signaling adapter, in regulating TLR7 and TLR9 signaling pathways that are crucial in the development of systemic lupus erythematosus (SLE). By studying how these pathways influence immune responses, particularly in B cells and plasmacytoid dendritic cells, the research aims to uncover mechanisms that lead to the production of harmful autoantibodies in lupus patients. The approach includes both laboratory experiments and analysis of immune cell behavior in the context of lupus. Patients may benefit from insights that could lead to new therapeutic targets for managing their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus (SLE).
Not a fit: Patients with other autoimmune diseases that do not involve TLR7 or TLR9 signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better control autoimmune responses in lupus patients.
How similar studies have performed: Previous research has shown that targeting TLR signaling pathways can be effective in managing autoimmune diseases, indicating potential for success in this approach.
Where this research is happening
Seattle, United States
- Benaroya Research Inst at Virginia Mason — Seattle, United States (Active)
Researchers
- Principal investigator: Hamerman, Jessica a — Benaroya Research Inst at Virginia Mason
- Study coordinator: Hamerman, Jessica a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.