Understanding how basal cells maintain their identity and function in the respiratory system
Investigating the Genetic and Epigenetic Control of Basal Cell Identity
This study looks at how special cells in your lungs, called basal cells, keep their unique traits and can change into different types of cells, even when they're separated from their usual surroundings or exposed to things like cigarette smoke, which could help us learn more about lung diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10998862 on NIH RePORTER |
What this research studies
This research investigates how basal cells, which are crucial for maintaining the respiratory tract's structure and function, preserve their specific characteristics over generations, even when isolated from their surrounding tissues. The study focuses on the intrinsic mechanisms that allow these cells to differentiate into various cell types, such as secretory and multiciliated cells, despite environmental changes like exposure to cigarette smoke. By analyzing the genetic and epigenetic factors involved, the research aims to uncover how these cells adapt and maintain their identity, which could have implications for understanding respiratory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with respiratory conditions, particularly those affected by chronic obstructive pulmonary disease (COPD) or similar airway issues.
Not a fit: Patients with non-respiratory conditions or those who do not have any basal cell-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating respiratory diseases by enhancing the regenerative capabilities of basal cells.
How similar studies have performed: Previous research has shown promising results in understanding cell differentiation and regeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Dirvin, Brooke Greer — Columbia University Health Sciences
- Study coordinator: Dirvin, Brooke Greer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.