Understanding how basal cells in the larynx help maintain health and respond to damage
Evaluating the role of epithelial basal cells in laryngeal homeostasis and disease development
This study is looking at how certain cells in the voice box help keep it healthy, especially when exposed to things like cigarette smoke, and aims to find new ways to treat laryngeal diseases so that patients can better protect their voice and breathing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11086145 on NIH RePORTER |
What this research studies
This research investigates the role of basal cells in the larynx, which are crucial for maintaining the health of this organ that is essential for breathing, swallowing, and voice production. The study focuses on how these cells respond to harmful substances like cigarette smoke and how their behavior changes in disease conditions. By examining the mechanisms of laryngeal epithelial regeneration and remodeling, the research aims to uncover insights that could lead to new therapies for laryngeal diseases. Patients may benefit from a better understanding of how to protect their laryngeal health and potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with laryngeal conditions, particularly those exposed to cigarette smoke or other harmful inhalants.
Not a fit: Patients with laryngeal conditions unrelated to environmental exposures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from laryngeal diseases caused by environmental insults.
How similar studies have performed: Previous research has shown promising results in understanding epithelial cell behavior in other organs, suggesting potential for success in this novel approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Direnzo, Elizabeth — Stanford University
- Study coordinator: Direnzo, Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.