Understanding how Barrett's Esophagus may progress to cancer
Official title: Modeling Neoplastic Progression in Barrett's Esophagus - Renewal -2
Funded at Arizona State University-Tempe Campus · NIH-11014342 · Data updated 2026-11-12
This study is looking at how cells in Barrett's Esophagus change over time to better understand the risk of developing esophageal cancer, helping doctors give more accurate predictions for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | February 7, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $429,747 |
| NIH project number | 5R01CA140657-13 |
| Project ID | NIH-11014342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Barrett's Esophagus who are concerned about their risk of developing esophageal adenocarcinoma.
✕Less likely to help
Patients without a diagnosis of Barrett's Esophagus or those who have already developed esophageal adenocarcinoma may not benefit from this research.
What this research studies
This research investigates the risk of esophageal adenocarcinoma in patients with Barrett's Esophagus by examining the evolutionary dynamics at the cellular level. The study aims to quantify how quickly and in what manner cells evolve in Barrett's tissue, which may help predict the likelihood of cancer development. By analyzing biopsies over time and space, researchers will assess various factors that influence cellular evolution, such as mutation rates and stem cell dynamics. This innovative approach seeks to provide a more reliable risk assessment for patients.
Why it matters
Potential benefit: If successful, this research could lead to better risk stratification for patients with Barrett's Esophagus, allowing for more personalized monitoring and treatment strategies.
How similar studies have gone: While the approach of measuring cellular evolution in this context is relatively novel, similar methodologies in cancer research have shown promise in predicting cancer risk and progression.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Maley, Carlo — Arizona State University-Tempe Campus
- Study coordinator: Maley, Carlo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.