Understanding how bariatric surgery and semaglutide affect adolescents' health
Physiologic response to bariatric surgery and the impact of adjunct semaglutide - in adolescents (the PRESSURE trial)
This study is looking at how weight loss surgery can help teenagers with severe obesity, and whether adding a medication called semaglutide can make the results even better, all while checking their health over a year to find out what helps them succeed.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11011271 on NIH RePORTER |
What this research studies
This research investigates the effects of metabolic and bariatric surgery (MBS) on adolescents with severe obesity, focusing on how physiological factors like gut peptides and metabolic rates influence weight loss outcomes. The study will also explore the potential benefits of adding semaglutide, a medication that may enhance the effects of surgery. By measuring various health indicators over a year, the research aims to identify predictors of success and improve long-term health outcomes for young patients. Participants will undergo assessments to evaluate their body composition, insulin sensitivity, and other cardiometabolic factors.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12 to 20 who are considering or have undergone bariatric surgery.
Not a fit: Patients who are not adolescents or those who do not have severe obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for adolescents undergoing bariatric surgery, enhancing their weight loss and overall health.
How similar studies have performed: Previous research has shown promising results in adult populations with similar approaches, but this specific focus on adolescents is relatively novel.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Moore, Jaime M. — University of Colorado Denver
- Study coordinator: Moore, Jaime M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.