Understanding how bariatric surgery affects Alzheimer's disease
Integrating spatial transcriptomics and single cell RNA-sequencing to mechanistically define bariatric surgery's impact on Alzheimer's Disease
['FUNDING_R03'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11140068
This study is looking at how weight loss surgery, like sleeve gastrectomy, might help improve brain health and reduce the risk of Alzheimer's in older adults who are dealing with obesity and type 2 diabetes, so you can learn more about how this surgery could benefit your overall health and thinking skills.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11140068 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of bariatric surgery, specifically sleeve gastrectomy, on Alzheimer's disease and metabolic health in older adults. By integrating advanced techniques like spatial transcriptomics and single-cell RNA sequencing, the study aims to uncover the biological mechanisms behind the surgery's impact on brain health. The research focuses on understanding how obesity and type 2 diabetes contribute to Alzheimer's risk and how surgical interventions can potentially mitigate these effects. Patients may benefit from insights into how weight loss surgery could improve cognitive function and overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who are experiencing obesity or metabolic issues.
Not a fit: Patients who are not experiencing obesity or metabolic disorders, or those younger than 65, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or slowing the progression of Alzheimer's disease in older adults.
How similar studies have performed: Previous research has shown promising results regarding the cognitive benefits of bariatric surgery in older adults, indicating that this approach may be effective.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HARRIS, DAVID A — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: HARRIS, DAVID A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.