Understanding how BAG3 protein affects neuron health and Alzheimer's disease
BAG3 regulates Rab35 and the ESCRT/endolysosome pathway
This study is looking at a protein called BAG3 to see how it helps keep brain cells healthy, especially in people with Alzheimer's disease, and it hopes to find new ways to protect these cells and improve treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10864970 on NIH RePORTER |
What this research studies
This research investigates the role of the BAG3 protein in maintaining the health of neurons, particularly in the context of Alzheimer's disease. It focuses on how BAG3 regulates the endolysosome system, which is crucial for protein quality control in neurons. By studying the mechanisms through which BAG3 influences neuronal integrity and the accumulation of tau protein, the research aims to uncover potential therapeutic targets for Alzheimer's disease. Patients may benefit from insights that could lead to new treatments aimed at protecting neuronal health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients with non-neurological conditions or those not affected by Alzheimer's disease may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by enhancing neuronal health.
How similar studies have performed: Previous research has shown promising results in understanding the role of protein quality control in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Johnson, Gail V. W. — University of Rochester
- Study coordinator: Johnson, Gail V. W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.