Understanding how BadR affects Lyme disease bacteria's ability to survive and infect hosts
Virulence regulation by BadR in the Lyme disease spirochete
This study is looking at a protein called BadR in the bacteria that causes Lyme disease to see how it helps the bacteria survive and adapt between ticks and humans, which could lead to better ways to understand and treat Lyme disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11017763 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called BadR in the Lyme disease-causing bacteria, Borrelia burgdorferi. The study focuses on how BadR regulates the bacteria's ability to adapt and thrive during its life cycle between ticks and mammals. By examining the genetic and biochemical pathways influenced by BadR, researchers aim to uncover new insights into the bacteria's infection mechanisms and survival strategies. This could lead to a better understanding of Lyme disease and potential new treatment approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Lyme disease or are at risk of infection due to tick exposure.
Not a fit: Patients who do not have Lyme disease or are not exposed to ticks may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Lyme disease by targeting the mechanisms that allow the bacteria to survive and infect hosts.
How similar studies have performed: Other research has shown success in understanding bacterial virulence factors, suggesting that this approach could yield valuable insights into Lyme disease.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Ouyang, Zhiming — University of South Florida
- Study coordinator: Ouyang, Zhiming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.