Understanding how bacteria's ribosomes work and how antibiotics affect them.
Official title: Structural basis for ribosome function and inhibition in bacteria.
Funded at University of Illinois at Chicago · NIH-11005290 · Data updated 2026-11-12
This study is looking at how ribosomes in bacteria help make proteins and how some antibiotics can stop them from working, which is important for finding new ways to fight infections, especially as some bacteria are becoming resistant to current treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | January 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $353,116 |
| NIH project number | 5R35GM151957-02 |
| Project ID | NIH-11005290 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
✕Less likely to help
Patients with infections that are not caused by bacterial pathogens or those who do not have antibiotic resistance issues may not benefit from this research.
What this research studies
This research investigates the ribosome, a crucial component in bacteria that synthesizes proteins. By utilizing advanced structural and biochemical techniques, the team aims to uncover how ribosomes function and how certain antibiotics can inhibit their activity. The study also explores the mechanisms behind antibiotic resistance, which is a growing concern in treating bacterial infections. Insights gained from this research could lead to the development of new strategies to combat antibiotic-resistant bacteria.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for bacterial infections, particularly those caused by antibiotic-resistant strains.
How similar studies have gone: Previous research has shown promising results in understanding ribosome function and antibiotic interactions, indicating that this approach has potential for success.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Polikanov, Yury — University of Illinois at Chicago
- Study coordinator: Polikanov, Yury
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.