Understanding how bacterial spores wake up and grow
Molecular basis of spore germination
This study is looking at how certain bacteria that can cause infections and spoil food wake up from a sleepy state and start growing when they sense nutrients, which could help us find better ways to stop these bacteria from making us sick or spoiling our food.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10873977 on NIH RePORTER |
What this research studies
This research investigates the process by which certain bacteria, known for causing infections and food spoilage, transition from a dormant spore state to active growth. By examining the molecular signals and mechanisms involved in spore germination, the study aims to uncover how these bacteria sense nutrients and initiate growth. The approach combines genetic, biochemical, computational, and structural methods to provide a comprehensive understanding of the germination process. This knowledge could lead to new strategies for preventing bacterial infections and foodborne illnesses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of infections caused by spore-forming bacteria, such as those with weakened immune systems or those undergoing antibiotic treatment.
Not a fit: Patients who are not affected by spore-forming bacterial infections or who do not have conditions that increase their risk of such infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for controlling bacterial infections and enhancing food safety.
How similar studies have performed: Other research has shown promise in understanding bacterial germination processes, indicating that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Rudner, David Z — Harvard Medical School
- Study coordinator: Rudner, David Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.