Understanding how bacterial spores wake up and grow
Studies of Bacterial Endospore Germination
['FUNDING_R01'] · VIRGINIA POLYTECHNIC INST AND ST UNIV · NIH-10669174
This study is looking into how tough bacterial spores can stay inactive for a long time and what makes them wake up and grow when conditions are right, which could help us understand how they survive in harsh environments and sometimes cause infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA POLYTECHNIC INST AND ST UNIV (nih funded) |
| Locations | 1 site (BLACKSBURG, UNITED STATES) |
| Trial ID | NIH-10669174 on ClinicalTrials.gov |
What this research studies
This research investigates the unique properties of bacterial endospores, which are incredibly resilient and can remain dormant for long periods. The study aims to uncover the mechanisms that allow these spores to sense favorable conditions and initiate germination, leading to active growth. By examining the structural and biochemical changes that occur during this process, researchers hope to gain insights into how these spores can survive extreme environments and potentially cause infections. The approach involves detailed analysis of the proteins and cellular components involved in spore dormancy and germination.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of infections caused by bacterial spores, such as those with compromised immune systems or those in agricultural settings.
Not a fit: Patients who are not at risk of infections from bacterial spores or who do not have underlying health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for controlling bacterial infections and enhancing food safety.
How similar studies have performed: Previous research has shown promise in understanding bacterial spore behavior, indicating that this area of study has potential for significant advancements.
Where this research is happening
BLACKSBURG, UNITED STATES
- VIRGINIA POLYTECHNIC INST AND ST UNIV — BLACKSBURG, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POPHAM, DAVID L — VIRGINIA POLYTECHNIC INST AND ST UNIV
- Study coordinator: POPHAM, DAVID L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Animal Diseases, Anthrax disease