Understanding how bacterial membranes affect the uptake of small molecules like antibiotics
Probing How Living Bacterial Membranes Control Small Molecule Uptake
['FUNDING_OTHER'] · UNIVERSITY OF TENNESSEE KNOXVILLE · NIH-10900568
This study is looking at how the unique structures of bacteria's outer layers affect how well antibiotics can get inside and work, which could help make these medicines more effective for people with infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE KNOXVILLE (nih funded) |
| Locations | 1 site (KNOXVILLE, UNITED STATES) |
| Trial ID | NIH-10900568 on ClinicalTrials.gov |
What this research studies
This research investigates how the complex structures of living bacterial membranes influence the way small molecules, particularly antibiotics, are absorbed and transported. Using advanced techniques like nonlinear spectroscopy and microscopy, the team will study living cells to gain insights into the behavior of these molecules within bacterial membranes. The research aims to identify key factors that affect the movement and organization of antibiotics in various bacterial species, which could lead to improved antibiotic effectiveness.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from bacterial infections, particularly those caused by antibiotic-resistant strains.
Not a fit: Patients with viral infections or those who do not have bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antibiotics that can better penetrate bacterial membranes.
How similar studies have performed: Previous research has shown promise in understanding bacterial membrane interactions, but this approach using living cells is relatively novel.
Where this research is happening
KNOXVILLE, UNITED STATES
- UNIVERSITY OF TENNESSEE KNOXVILLE — KNOXVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CALHOUN, TESSA RAE — UNIVERSITY OF TENNESSEE KNOXVILLE
- Study coordinator: CALHOUN, TESSA RAE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.