Understanding how bacterial chromosomes are organized
Official title: Investigating regulators of bacterial chromosome organization
Funded at University of Washington · NIH-10937922 · Data updated 2026-11-12
This study is looking at how bacteria organize their DNA and what helps keep it all packed neatly inside their cells, which could help scientists find new ways to treat bacterial infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $441,250 |
| NIH project number | 1R35GM154727-01 |
| Project ID | NIH-10937922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for potential benefit from this research include individuals with bacterial infections that are resistant to current antibiotic treatments.
✕Less likely to help
Patients with viral infections or non-bacterial conditions are unlikely to benefit from this research.
What this research studies
This research investigates the organization of bacterial chromosomes, focusing on the mechanisms that regulate their packaging within cells. By utilizing advanced techniques like 3D chromosome capture, the study aims to uncover how DNA supercoiling and nucleoid-associated proteins influence chromosome structure. This understanding could reveal vulnerabilities in bacterial genomes that may be targeted for new therapeutic approaches. The research will involve detailed analysis of the bacterium Caulobacter crescentus to explore these regulatory mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibacterial therapies by identifying targets within bacterial chromosome organization.
How similar studies have gone: Other research has shown success in understanding chromosome organization in bacteria, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Guo, Monica S. — University of Washington
- Study coordinator: Guo, Monica S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.