Understanding how bacteria use ethanolamine for survival
Elucidating the parameters of intracellular ethanolamine utilization
This study is looking at how a harmful bacteria called Listeria uses a substance found in our bodies to grow and survive during infections, which could help us understand how it causes illness and lead to better treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11117468 on NIH RePORTER |
What this research studies
This research investigates how certain bacteria, particularly the human pathogen Listeria monocytogenes, utilize ethanolamine as a source of energy and nutrients during infection. The study aims to identify the specific genes involved in this process and their expression during the bacteria's lifecycle within host cells. By examining the intracellular environment where this utilization occurs, the research seeks to fill critical gaps in our understanding of bacterial metabolism and pathogenicity. This could lead to new insights into how these bacteria survive and replicate inside the human body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of infections caused by Listeria monocytogenes, such as pregnant women, newborns, and immunocompromised patients.
Not a fit: Patients with infections caused by bacteria that do not utilize ethanolamine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections caused by Listeria monocytogenes and similar pathogens.
How similar studies have performed: While the specific focus on ethanolamine utilization in Listeria monocytogenes is novel, similar research on bacterial metabolism has shown promising results in understanding pathogen survival.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Garsin, Danielle a — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Garsin, Danielle a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.