Understanding how bacteria use CRISPR-Cas systems to fight infections and manage antibiotic resistance
Non-canonical functions of Cas9 andthe cell biology of CRISPR-Cas immunity
This study looks at how a special protein called Cas9 helps bacteria remember and fight off harmful viruses and other genetic threats, which could lead to better ways to tackle antibiotic resistance.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11083564 on NIH RePORTER |
What this research studies
This research investigates the unique roles of the Cas9 protein in bacterial immunity, particularly how it helps bacteria remember and destroy harmful genetic elements like viruses and plasmids. By studying the interactions between CRISPR-Cas systems and their bacterial hosts, the research aims to uncover how these systems regulate their activity to balance defense against infections with the need for genetic exchange. The approach includes exploring the autoregulatory functions of Cas9 and how it can be activated during infections, which could lead to new insights into combating antibiotic resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with viral infections or those not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative strategies for managing antibiotic resistance and improving treatments for bacterial infections.
How similar studies have performed: Previous research has shown promising results in understanding CRISPR-Cas systems, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Modell, Joshua — Johns Hopkins University
- Study coordinator: Modell, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.