Understanding how bacteria transport proteins to their outer membrane
Official title: Lipoprotein trafficking to the bacterial outer membrane
Funded at Emory University · NIH-11015573 · Data updated 2026-11-12
This study is looking at how certain harmful bacteria, like Acinetobacter baumannii, move important proteins to their outer layer, which helps them survive and resist antibiotics, with the hope of finding new ways to create better treatments for infections caused by these tough bacteria.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | January 27, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $440,327 |
| NIH project number | 1R35GM156739-01 |
| Project ID | NIH-11015573 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from infections caused by antibiotic-resistant Gram-negative bacteria, particularly those caused by Acinetobacter baumannii.
✕Less likely to help
Patients with infections caused by Gram-positive bacteria or those not affected by antibiotic resistance may not benefit from this research.
What this research studies
This research investigates the mechanisms by which Gram-negative bacteria, such as Acinetobacter baumannii, transport essential proteins to their outer membrane. The study focuses on the role of lipoproteins and the molecular machines involved in their transport, which is crucial for the bacteria's survival and resistance to antibiotics. By exploring these processes, the research aims to identify new targets for antibiotic development, potentially leading to more effective treatments for infections caused by antibiotic-resistant bacteria.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that are effective against resistant bacterial infections.
How similar studies have gone: Previous research has shown success in targeting bacterial transport mechanisms, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Grabowicz, Marcin — Emory University
- Study coordinator: Grabowicz, Marcin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.