Understanding how bacteria transport important molecules across their membranes
Structure and function of MCE systems in bacteria
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-10892786
This study is looking at how bacteria move important substances in and out of their cells, especially how this helps them resist antibiotics, and it's for anyone interested in understanding how we might fight antibiotic resistance better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10892786 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which bacteria transport essential molecules across their cell membranes, focusing on the bacterial outer membrane's role in antibiotic resistance. The team studies specific protein families, known as MCE systems, that may form structures to facilitate the movement of lipids and other hydrophobic substances. By employing advanced techniques like cryo-electron microscopy and X-ray crystallography, the researchers aim to uncover the structural details of these transport systems and how they function. This knowledge could lead to new strategies for combating antibiotic resistance in bacteria.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections caused by non-bacterial pathogens or those not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments that enhance the effectiveness of antibiotics against resistant bacterial strains.
How similar studies have performed: Other research has shown promising results in understanding bacterial transport mechanisms, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EKIERT, DAMIAN CHARLES — JOHNS HOPKINS UNIVERSITY
- Study coordinator: EKIERT, DAMIAN CHARLES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.