Understanding how bacteria survive stress and resist antibiotics
The critical roles of (p)ppGpp in homeostasis and antibiotic tolerance in Gram positive bacteria
This study looks at how certain bacteria, like those that can cause infections, react to tough situations like not having enough food or being exposed to antibiotics, and it focuses on a special molecule that helps them survive; the goal is to find new ways to treat infections that are hard to beat with current medicines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11035175 on NIH RePORTER |
What this research studies
This research investigates how certain bacteria, particularly Gram-positive types like Bacillus anthracis and Bacillus subtilis, respond to various stresses such as nutrient shortages and antibiotic exposure. The focus is on a signaling molecule called (p)ppGpp, which helps bacteria adapt and survive under these challenging conditions. By studying how (p)ppGpp influences bacterial behavior and resistance, the research aims to uncover new mechanisms that could lead to better treatments for antibiotic-resistant infections. Patients may benefit from insights gained into how to combat these resilient bacteria effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant Gram-positive bacteria.
Not a fit: Patients with infections caused by Gram-negative bacteria or those not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating antibiotic-resistant bacterial infections.
How similar studies have performed: Other research has shown promising results in understanding bacterial stress responses, making this approach a continuation of established scientific inquiry.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Wang, Jue D. — University of Wisconsin-Madison
- Study coordinator: Wang, Jue D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.