Understanding how bacteria share genes that cause antibiotic resistance
Mechanisms and regulation of horizontal gene transfer by natural transformation in Vibrio cholerae
This project explores how bacteria like Vibrio cholerae exchange genetic material, which helps us understand how they become resistant to antibiotics.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-11095826 on NIH RePORTER |
What this research studies
Our bodies are home to many bacteria, and some can cause infections that are hard to treat because they become resistant to antibiotics. This project uses a bacterium called Vibrio cholerae, known for causing cholera, as a model to learn how bacteria share genes. We are focusing on a process called natural transformation, where bacteria take up DNA from their environment. By understanding how this process works and how it's controlled, we hope to find new ways to fight infections that are resistant to current medicines.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patients, but future clinical applications could benefit individuals with bacterial infections, especially those resistant to antibiotics.
Not a fit: Patients not affected by bacterial infections or antibiotic resistance would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing and treating antibiotic-resistant infections, which are a growing global health concern.
How similar studies have performed: This project builds upon well-established model systems and existing genetic tools, suggesting a solid foundation for exploring new mechanisms of gene transfer.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Dalia, Ankur — Trustees of Indiana University
- Study coordinator: Dalia, Ankur
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.