Understanding how bacteria respond to metabolic stress
Official title: Analysis of Metabolic Stress and Functional Integration in Prokaryotes
Funded at University of Georgia · NIH-11061039 · Data updated 2026-11-12
This study is looking at how bacteria react to different stresses, which could help us learn more about how our own bodies deal with similar challenges, especially when it comes to diseases related to metabolism and antibiotic resistance, ultimately aiming to improve treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $377,500 |
| NIH project number | 5R35GM153189-02 |
| Project ID | NIH-11061039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with metabolic disorders or those affected by antibiotic-resistant infections.
✕Less likely to help
Patients with non-metabolic related conditions or those not affected by antibiotic resistance may not receive direct benefits from this research.
What this research studies
This research investigates the biochemical pathways in bacteria that respond to various environmental and internal stresses. By using a combination of genetics, molecular biology, and advanced techniques like bioinformatics and metabolomics, the study aims to uncover how these metabolic networks function and adapt. Insights gained from this research could help in understanding similar processes in humans, particularly in relation to diseases linked to metabolic dysfunction. The ultimate goal is to inform drug design and treatment strategies for metabolic diseases and antibiotic resistance.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating metabolic diseases and combating antibiotic resistance.
How similar studies have gone: Previous research has shown success in understanding metabolic pathways in model organisms, suggesting potential for breakthroughs in human applications.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Downs, Diana M. — University of Georgia
- Study coordinator: Downs, Diana M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.