Understanding how bacteria resist antibiotics using human organoids
Organoid Cultivation Core
This study is all about growing tiny versions of human organs, like the vagina and bladder, to see how bacteria and our body's own factors can lead to infections and antibiotic resistance, helping researchers find better ways to understand and treat these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11049074 on NIH RePORTER |
What this research studies
This research focuses on developing human organoids from various tissues, such as the vagina, bladder, and nasal airway, to study how bacteria and host factors contribute to antibiotic resistance and infections. By creating these organoid cultures, researchers aim to test hypotheses about the role of the host epithelium in bacterial infections. The Organoid Cultivation Core will streamline the process of isolating and maintaining these organoids, making it easier and more cost-effective for researchers to conduct their projects. This approach allows for more accurate and relevant biological insights that could lead to better understanding and treatment of bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are experiencing or are at risk of antibiotic-resistant bacterial infections.
Not a fit: Patients with infections that are not caused by bacteria or those who do not have antibiotic resistance issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for combating antibiotic-resistant infections in patients.
How similar studies have performed: Other research has shown promise in using organoid models to study bacterial infections and antibiotic resistance, indicating that this approach is both relevant and potentially impactful.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Blutt, Sarah E — Baylor College of Medicine
- Study coordinator: Blutt, Sarah E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.