Understanding how bacteria resist antibiotics and finding ways to overcome this resistance
Official title: Intrinsic Ribosomal Decoding Center Methylation and the Bacterial Antibiotic Response
Funded at Emory University · NIH-10997745 · Data updated 2026-11-12
This study is looking at how certain bacteria become resistant to important antibiotics, which can help us find new ways to treat infections and improve options for patients dealing with tough-to-treat bacteria.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 11, 2024 |
| Project end | July 10, 2028 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AI186518-01 |
| Project ID | NIH-10997745 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from infections caused by aminoglycoside-resistant bacteria.
✕Less likely to help
Patients with infections caused by bacteria that are not resistant to aminoglycosides may not benefit from this research.
What this research studies
This research investigates the mechanisms by which bacteria develop resistance to aminoglycoside antibiotics, which are critical for treating infections. It focuses on the role of specific enzymes that modify the ribosomal RNA in bacteria, making them resistant to these antibiotics. By studying these mechanisms, the research aims to identify new targets for antibiotic development and explore ways to restore the effectiveness of existing antibiotics. Patients may benefit from new treatment options that could emerge from this work, especially those with infections caused by resistant bacteria.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating bacterial infections that are currently difficult to manage due to antibiotic resistance.
How similar studies have gone: Previous research has shown promise in targeting bacterial resistance mechanisms, indicating that this approach could lead to significant advancements in antibiotic treatment.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Barmada, Mohamed I — Emory University
- Study coordinator: Barmada, Mohamed I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.