Understanding how bacteria regulate their genes and resist antibiotics
High Resolution Characterization of Bacterial Epigenomes and Microbiome
This study is looking at how bacteria manage their genes and become resistant to antibiotics, using special technology to get a closer look at their DNA, which could help us find better ways to fight infections and tackle antibiotic resistance.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11007169 on NIH RePORTER |
What this research studies
This research investigates the complex ways bacteria control their genes and develop resistance to antibiotics. By using advanced techniques like Single Molecule Real-Time (SMRT) sequencing, the project aims to profile bacterial DNA methylation at a very detailed level. This could reveal how bacteria adapt and survive in various environments, including their interactions with human hosts. The findings may lead to new strategies for combating antibiotic resistance and improving treatments for bacterial infections.
Who could benefit from this research
Good fit: Patients suffering from infections caused by antibiotic-resistant bacteria would be ideal candidates to benefit from this research.
Not a fit: Patients with viral infections or those not affected by bacterial infections may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative approaches for treating antibiotic-resistant infections.
How similar studies have performed: Previous research has shown promising results in understanding bacterial epigenomes, indicating that this approach could yield significant insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Fang, Gang — Icahn School of Medicine at Mount Sinai
- Study coordinator: Fang, Gang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.