Understanding how bacteria regulate their cell wall enzymes
Molecular mechanisms of peptidoglycan endopeptidase regulation
This study is looking at how certain enzymes in the bacteria that cause cholera help build and break down their cell walls, especially when antibiotics are used, to find better ways to fight antibiotic resistance and make antibiotics work better for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10980739 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that control enzymes responsible for maintaining and breaking down the bacterial cell wall, particularly in the context of antibiotic treatment. By focusing on the bacteria Vibrio cholerae, the study aims to uncover how specific enzymes, known as endopeptidases, are regulated during normal growth and in response to antibiotics. The research employs a combination of genetic, biochemical, and microbiological techniques to explore these regulatory processes. Insights gained could lead to improved strategies for combating antibiotic resistance and enhancing the effectiveness of existing antibiotics.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from bacterial infections, particularly those caused by antibiotic-resistant strains.
Not a fit: Patients with viral infections or those not affected by antibiotic-resistant bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new approaches for treating bacterial infections and overcoming antibiotic resistance.
How similar studies have performed: Previous research has shown success in understanding bacterial cell wall mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Doerr, Tobias — Cornell University
- Study coordinator: Doerr, Tobias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.