Understanding how bacteria regulate their cell envelope using a specific molecule.
Official title: Molecular basis of cyclic-di-AMP regulation in Gram-positive bacteria
Funded at Harvard Medical School · NIH-10991067 · Data updated 2026-11-12
This study looks at how certain bacteria keep their protective outer layer in good shape, focusing on a special molecule that helps them fix problems when their envelope gets damaged, which could lead to new ways to tackle antibiotic resistance.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $36,983 |
| NIH project number | 1F31AI181098-01A1 |
| Project ID | NIH-10991067 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by Gram-positive bacteria, particularly those with antibiotic-resistant strains.
✕Less likely to help
Patients with infections caused by Gram-negative bacteria or those not affected by antibiotic resistance may not benefit from this research.
What this research studies
This research investigates how Gram-positive bacteria monitor and repair their cell envelope, which is crucial for their growth and survival. It focuses on a molecule called cyclic-di-AMP, which helps bacteria respond to defects in their envelope. By studying how bacteria adjust the levels of this molecule, the research aims to uncover new insights into antibiotic resistance and the mechanisms behind bacterial survival. The approach includes examining the interactions between specific proteins that regulate cyclic-di-AMP synthesis in response to envelope stress.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating antibiotic resistance in bacterial infections.
How similar studies have gone: Other research has shown promising results in understanding bacterial regulation mechanisms, but this specific approach focusing on cyclic-di-AMP is relatively novel.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Brogan, Anna P — Harvard Medical School
- Study coordinator: Brogan, Anna P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.