Understanding how bacteria produce and use complex carbohydrates
Synthesis, secretion and assembly of extracellular complex carbohydrates in Gram-negative bacteria
This study is looking at how certain bacteria make and release important sugars that help them function, and it's for anyone interested in understanding how we might develop better treatments for bacterial infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10997416 on NIH RePORTER |
What this research studies
This research investigates the synthesis and secretion of complex carbohydrates by Gram-negative bacteria, which are crucial for various cellular functions. By employing a combination of structural biology, biochemistry, and molecular biology, the study aims to uncover the mechanisms behind how these carbohydrates are produced and integrated into bacterial cell surfaces. The research utilizes various model systems, including microbes and plants, to provide detailed insights into these processes. This knowledge could lead to advancements in drug development and biomaterials that target bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic bacterial infections, particularly those related to biofilm-forming bacteria.
Not a fit: Patients with viral infections or non-bacterial related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for bacterial infections and improved biomaterials for medical applications.
How similar studies have performed: Other research has shown promise in understanding bacterial polysaccharide mechanisms, suggesting potential for significant advancements in this area.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Zimmer, Jochen — University of Virginia
- Study coordinator: Zimmer, Jochen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.