Understanding how bacteria organize their chromosomes
How bacterial SMC complexes organize chromosomes
This study is looking at how certain bacterial proteins help organize and separate DNA during cell division, which could lead to new insights that might help improve medical treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-11044186 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which bacterial SMC complexes organize and segregate chromosomes during cell division. By utilizing advanced techniques such as 3C-based assays, the study aims to uncover how these complexes interact with DNA and other proteins to facilitate chromosome structure and function. The research involves both in vivo and in vitro experiments to provide a comprehensive understanding of the role of ATP hydrolysis in DNA loop extrusion. Patients may benefit from insights gained into fundamental biological processes that could inform future medical applications.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders related to chromosomal abnormalities.
Not a fit: Patients with conditions unrelated to chromosomal organization or genetic disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding chromosome organization, which may have implications for treating genetic disorders and improving gene therapy techniques.
How similar studies have performed: Other research has shown success in understanding chromosome organization through similar approaches, indicating that this area of study is both relevant and promising.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Wang, Xindan — Trustees of Indiana University
- Study coordinator: Wang, Xindan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.