Understanding how bacteria manage stress and resistance to antibiotics
Official title: Cross-species Analysis of Bacterial Gene Networks
Funded at University of Wisconsin-Madison · NIH-10877809 · Data updated 2026-11-12
This study is looking at how certain bacteria, like E. coli and Klebsiella, manage to survive when faced with antibiotics and how they interact with their surroundings, including our bodies, to find ways to help us understand and potentially weaken their defenses against these medicines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $382,090 |
| NIH project number | 5R35GM150487-02 |
| Project ID | NIH-10877809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with infections caused by antibiotic-resistant bacteria may benefit from the findings of this research.
✕Less likely to help
Patients with viral infections or those not affected by antibiotic resistance may not receive direct benefits from this research.
What this research studies
This research investigates the genetic networks that help bacteria survive antibiotic stress and interact with their environment, including the human microbiome. By comparing these networks across different bacterial species, specifically Escherichia coli, Enterobacter cloacae, and Klebsiella pneumoniae, the research aims to uncover how genetic variations influence bacterial behavior and resistance. Utilizing advanced CRISPR-based tools, the study will explore gene functions and regulatory mechanisms at a genomic level, providing insights into potential vulnerabilities in bacterial defenses against antibiotics.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating antibiotic resistance in bacterial infections.
How similar studies have gone: Previous research has shown success in using CRISPR-based methods to study gene functions in bacteria, indicating a promising approach for this investigation.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Peters, Jason M. — University of Wisconsin-Madison
- Study coordinator: Peters, Jason M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.