Understanding how bacteria manage metal nutrients
Tracking, elucidation and modulation of xenometal homeostasis in bacteria
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10914124
This study looks at how bacteria gather important metal nutrients they need to grow and cause infections, and it aims to find new ways to create antibiotics by understanding these processes better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10914124 on ClinicalTrials.gov |
What this research studies
This research investigates how bacteria acquire and regulate essential metal ions, which are crucial for their growth and virulence. It focuses on the mechanisms bacteria use to access metal ions from their environment, particularly in the presence of competing non-essential metals. By studying the interactions between bacterial metallophores and metal ions, the research aims to explore new therapeutic strategies that could leverage these pathways to develop alternative antibiotics. The approach includes advanced techniques to analyze metal ion behavior and its impact on bacterial gene regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with bacterial infections that are resistant to current antibiotic treatments.
Not a fit: Patients with viral infections or those who do not have bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antibiotics that target bacterial metal ion homeostasis, potentially overcoming antibiotic resistance.
How similar studies have performed: Other research has shown promise in utilizing bacterial metal homeostasis pathways for therapeutic purposes, indicating potential for success in this area.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOROS, ESZTER — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: BOROS, ESZTER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.