Understanding how bacteria interact in the lungs of cystic fibrosis patients
Metabolic Basis of Bacterial Community Function in the Cystic Fibrosis Airway
This study is looking at how different bacteria in the lungs of people with cystic fibrosis work together and affect lung infections, with the hope of finding better ways to treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11093365 on NIH RePORTER |
What this research studies
This research investigates the complex interactions among bacterial communities in the lungs of patients with cystic fibrosis (CF). By utilizing advanced bioinformatics and computational modeling, the study aims to uncover how these interactions contribute to persistent lung infections that are resistant to antibiotics. The research combines laboratory experiments with big data analysis to better understand the metabolic processes that affect treatment outcomes for CF patients. Ultimately, the goal is to improve therapeutic strategies for managing CF-related infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cystic fibrosis who experience recurrent lung infections.
Not a fit: Patients without cystic fibrosis or those who do not have chronic lung infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic lung infections in cystic fibrosis patients.
How similar studies have performed: Previous research has shown that understanding microbial interactions can lead to breakthroughs in treating polymicrobial infections, suggesting potential success for this approach.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: O'toole, George a. — Dartmouth College
- Study coordinator: O'toole, George a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.