Understanding how bacteria influence B cell tumors and their treatment
Official title: Novel mechanisms of B cell tumorigenesis and relapse
Funded at Rutgers, the State Univ of N.j. · NIH-11098770 · Data updated 2026-11-12
This study is looking at how the bacteria that naturally live in our bodies might influence the growth and return of certain blood cancers called B cell malignancies, with the hope of finding better treatments for patients dealing with these types of cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $390,932 |
| NIH project number | 5R01CA293055-02 |
| Project ID | NIH-11098770 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with B cell malignancies, such as lymphomas or myelomas.
✕Less likely to help
Patients with non-B cell malignancies or those who do not have a diagnosis of cancer may not benefit from this research.
What this research studies
This research investigates the role of commensal bacteria in the development and relapse of B cell malignancies, which are a significant portion of blood cancers. The project aims to uncover new mechanisms by which these bacteria may affect B cell tumorigenesis and treatment resistance. By studying the interactions between B cells and bacterial antigens, the research seeks to provide insights that could lead to improved therapies for patients with B cell cancers. The approach includes examining the tumor microenvironment and the immune responses triggered by bacterial components.
Why it matters
Potential benefit: If successful, this research could lead to novel treatment strategies that improve outcomes for patients with B cell malignancies.
How similar studies have gone: While the role of bacteria in other cancers has been studied, this specific approach to B cell malignancies is relatively novel and has not been extensively tested.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Xie, Ping — Rutgers, the State Univ of N.j.
- Study coordinator: Xie, Ping
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.